清华大学发现移植脂肪干细胞促进阿尔茨海默症的神经发生
发布于 2014年7月14日 星期一 08:47
        近年的研究表明,间充质干细胞移植可以刺激成年鼠类模型动物脑内的神经发生,并且在脑缺血等病理条件下改善模型动物的组织和功能损伤。但针对脂肪干细胞移植对阿尔茨海默病模型小鼠的治疗效果,对模型小鼠脑内氧化损伤水平以及神经发生过程的影响,一直鲜有研究。
 
        中国清华大学闫玉芳博士所在研究团队,在APP/PS1转基因阿尔茨海默症模型小鼠海马区域植入脂肪干细胞,发现脂肪干细胞可以减轻模型小鼠脑内的氧化损伤,促进颗粒下和脑内室管膜下区域的神经发生过程,进而改善APP/PS1转基因阿尔茨海默症模型小鼠的认知功能。这为应用脂肪干细胞移植治疗阿尔茨海默症提供了一定的理论与实验依据。相关文献发表于《中国神经再生研究(英文版)》杂志2014年4月第8期。
 
原文摘要:
 
Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice
 
Yufang Yan, Tuo Ma, Kai Gong, Qiang Ao, Xiufang Zhang, Yandao Gong
 
In the present study, we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer's disease model mice. Immunofluorescence staining revealed that the number of newly generated (BrdU + ) cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer's disease mice after adipose-derived mesenchymal stem cell transplantation, and there was also a significant increase in the number of BrdU + /DCX + neuroblasts in these animals. Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well. Furthermore, adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice. Based on these findings, we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer's disease mice, thereby facilitating functional recovery.
Copyright © Amcellgene co. 2015 All Rights Reserved 版权所有:天津昂赛细胞基因工程有限公司    津ICP备14006482号-3